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Unformatted text preview: zone at the Epiphyseal end, moving distally into a proliferative and then hyper trophic zone and ending with a band of ossifying cartilage (the metaphysis). The growth plate is clinically relevant in that it is often the primary site for infection, metastasis, fractures and the effects of endocrine bone disorders. The Epiphyseal plate can be broken down into 5 zones: 1. Resting Zone 2. Proliferative Zone 3. Hypertrophic Zone 4. Provisional Calcification 5. Ossification Zone Factors Influencing Bone Growth Hormones Human growth hormone Insulin - like growth factor Sex hormones Insulin Thyroid hormone Calcitonin Parathyroid hormone Vitamins o A, B 12 , C and D Minerals o Calcium, Phosphorus, Magnesium, Manganese Healing of Fractures Understanding is pivotal in the appreciation of how fractures should be treated Process of fracture healing is different in dense cortical bone from that in spongy cancellous bone...
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