{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

Epiphyseal plate

Epiphyseal plate - zone at the Epiphyseal end moving...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Epiphyseal plate The Epiphyseal plate is a hyaline cartilage plate in the metaphyses of children and adolescents. Whereas endochondral ossification is responsible for the initial bone development from cartilage in utero and infants, the Epiphyseal plate is responsible for longitudinal growth of bones. The plate's Chondrocytes are under constant division by mitosis. These daughter cells stack facing the epiphysis while the older cells are pushed towards the diaphysis. As the older Chondrocytes degenerate, osteoblasts ossify the remains to form new bone. Around the end of puberty, the Epiphyseal cartilage cells stop duplicating and the entire cartilage is slowly replaced by bone, leaving only a thin Epiphyseal line. Once the adult stage is reached, the only way to manipulate height is modifying bone length via distraction Osteogenesis. The growth plate has a very specific morphology in having a zonal arrangement. The growth plate includes a relatively inactive reserve
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Background image of page 2
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: zone at the Epiphyseal end, moving distally into a proliferative and then hyper trophic zone and ending with a band of ossifying cartilage (the metaphysis). The growth plate is clinically relevant in that it is often the primary site for infection, metastasis, fractures and the effects of endocrine bone disorders. The Epiphyseal plate can be broken down into 5 zones: 1. Resting Zone 2. Proliferative Zone 3. Hypertrophic Zone 4. Provisional Calcification 5. Ossification Zone Factors Influencing Bone Growth Hormones • Human growth hormone • Insulin - like growth factor • Sex hormones • Insulin • Thyroid hormone • Calcitonin • Parathyroid hormone • Vitamins o A, B 12 , C and D • Minerals o Calcium, Phosphorus, Magnesium, Manganese Healing of Fractures • Understanding is pivotal in the appreciation of how fractures should be treated • Process of fracture healing is different in dense cortical bone from that in spongy cancellous bone...
View Full Document

{[ snackBarMessage ]}

Page1 / 2

Epiphyseal plate - zone at the Epiphyseal end moving...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon bookmark
Ask a homework question - tutors are online