Epiphyseal plate

Epiphyseal plate - zone at the Epiphyseal end, moving...

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Epiphyseal plate The Epiphyseal plate is a hyaline cartilage plate in the metaphyses of children and adolescents. Whereas endochondral ossification is responsible for the initial bone development from cartilage in utero and infants, the Epiphyseal plate is responsible for longitudinal growth of bones. The plate's Chondrocytes are under constant division by mitosis. These daughter cells stack facing the epiphysis while the older cells are pushed towards the diaphysis. As the older Chondrocytes degenerate, osteoblasts ossify the remains to form new bone. Around the end of puberty, the Epiphyseal cartilage cells stop duplicating and the entire cartilage is slowly replaced by bone, leaving only a thin Epiphyseal line. Once the adult stage is reached, the only way to manipulate height is modifying bone length via distraction Osteogenesis. The growth plate has a very specific morphology in having a zonal arrangement. The growth plate includes a relatively inactive reserve
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Unformatted text preview: zone at the Epiphyseal end, moving distally into a proliferative and then hyper trophic zone and ending with a band of ossifying cartilage (the metaphysis). The growth plate is clinically relevant in that it is often the primary site for infection, metastasis, fractures and the effects of endocrine bone disorders. The Epiphyseal plate can be broken down into 5 zones: 1. Resting Zone 2. Proliferative Zone 3. Hypertrophic Zone 4. Provisional Calcification 5. Ossification Zone Factors Influencing Bone Growth Hormones Human growth hormone Insulin - like growth factor Sex hormones Insulin Thyroid hormone Calcitonin Parathyroid hormone Vitamins o A, B 12 , C and D Minerals o Calcium, Phosphorus, Magnesium, Manganese Healing of Fractures Understanding is pivotal in the appreciation of how fractures should be treated Process of fracture healing is different in dense cortical bone from that in spongy cancellous bone...
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This note was uploaded on 11/22/2011 for the course BSC BSC1085 taught by Professor Sharonsimpson during the Fall '10 term at Broward College.

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Epiphyseal plate - zone at the Epiphyseal end, moving...

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