HÃœRTHLE CELL TUMORS AND CANCER

HÃœRTHLE CELL TUMORS AND CANCER - HRTHLE CELL...

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Unformatted text preview: HRTHLE CELL TUMORS AND CANCER Hrthle cell tumors are thought to be variants of follicular neoplasms, but others regard them as a totally separate disease entity. 38a They are more difficult to treat than the usual follicular neoplasms, however, for several reasons 38 : (1) the incidence of carcinoma varies from 5.3% to 62% in different clinical series; (2) benign-appearing tumors later metastasize in up to 2.5% of patients; and (3) Hrthle cell cancers are far less likely to concentrate radioiodine than are the usual follicular carcinomas, which makes treatment of metastatic disease particularly difficult. The difficulty in diagnosing Hurtle cell cancers and differentiating them from benign lesions is shown in the following study. Of 54 patients with Hrthle cell tumors whom we treated, 38 4 had grossly malignant lesions, 10 had questionable diagnoses (intermediate lesions) because of partial penetration of their capsule by tumor, and 40 (74%) had lesions that were thought to be...
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