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Skin Cancer - growth and metastasizes to adjacent lymph...

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Skin Cancer: Most are benign and do not spread. Some are malignant and invasive. The most important risk factor is over exposure to U.V. radiation. Basal Cell Carcinoma: Least malignant. Most common. Cells of the S. basale are altered and can't form keratin, and no longer honor the boundary between epidermis and dermis. Cells proliferate, invading the dermis and the hypodermic.Occur in areas of the face and appear as shiny, dome-shaped nodules that later develop a central ulcer with a "pearly" beaded edge. Slow grower, seldom metastasizes. 99% cure rate with surgery. Squamous Cell Carcinoma: Arises from keratinocytes in the S. spinosum. Lesions appear as a scaly reddened papule that gradually forms a shallow ulcer with a firm raised border. Appears most often on the scalp, ears, dorsum of the hands, and lower lip. Rapid
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Unformatted text preview: growth and metastasizes to adjacent lymph nodes if not removed. Good cure rate if caught early; removed surgically or radiation therapy. • Malignant Melanoma: Cancer of the melanocytes. Accounts for 5% of skin cancers; incidence increasing rapidly. Deadly. Begins wherever there is pigment. Most appear spontaneously. Appear as a spreading brown to black patch that metastasizes rapidly to surrounding lymph and blood vessels. Survival is poor, but early detection helps. ABCD rule: A: asymmetry - 2 sides do not match B: irregular border - not smooth C: color - pigmented spot D: diameter - larger than 6mm Therapy is wide surgical excision and chemotherapy....
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