Sliding filament theory

Sliding filament theory - • Muscle fiber contraction •...

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Sliding filament theory • Explains the relationship between thick and thin filaments as contraction proceeds • Cyclic process beginning with calcium release from SR • Calcium binds to troponin • Trponin moves, moving tropomyosin and exposing actin active site • Myosin head forms cross bridge and bends toward H zone • ATP allows release of cross bridge The Contraction of Skeletal Muscle Tension • Created when muscles contract • Series of steps that begin with excitation at the neuromuscular junction • Calcium release • Thick/thin filament interaction
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Unformatted text preview: • Muscle fiber contraction • Tension Control of skeletal muscle activity occurs at the neuromuscular junction • Action potential arrives at synaptic terminal • ACh released into synaptic cleft • ACh binds to receptors on post-synaptic neuron • Action potential in sarcolemma Excitation/contraction coupling • Action potential along T-tubule causes release of calcium from cisternae of SR • Initiates contraction cycle • Attachment • Pivot • Detachment • Return Relaxation • Acetylcholinesterase breaks down ACh • Limits the duration of contraction...
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