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Synthesis matrix of Intramembranous Osteogenesis

Synthesis matrix of Intramembranous Osteogenesis -...

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Synthesis matrix of Intramembranous Osteogenesis Type 1 Collagen Proteoglycans Glycoproteins Alkaline Phosphatase Osteoblasts o Do not divide o Transformation into Osteocytes Intramembranous Osteogenesis Remodelling Osteoclasts form from monocytic-macrophage system Multinucleated Resorption craters are clearly seen Resorb mineralised bone matrix Osteoclast activity > Osteoblast activity Endochondral Osteogenesis This method of bone development builds on an existing cartilage model Examples include: Long bones Vertebrae Ribs Pelvis 1. Chondrocytes undergo hypertrophy and secrete extracellular matrix which calcifies resulting in chondrocyte cell death 2. Osteogenic buds invade the dead cartilage - blood vessels bringing osteogenic cells. Osteoblasts develop which secrete more matrix which in turn becomes
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Unformatted text preview: calcified 3. Gradual replacement of cartilage by woven bone 4. Perichondrium becomes the periosteum. Note a few mesenchymal cells deep to the perichondrium undergo intramembranous ossification Primary Ossification Centres • Primary Ossification Centre expand Longitudinally • Increased Growth of Periosteal Bone Collar • By 6 th months resorption of central part results in the formation of a medullary cavity • Immature woven bone gradually replaced by lamellar bone Secondary Bone • Develops in the cartilage at the ends of the long bones - Epiphysis • At birth, secondary centre in femur, others appear in cartilaginous epiphyses at varying ages after birth • No perichondrium in the area of articular cartilage and so no periosteum in this area...
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