This preview shows page 1. Sign up to view the full content.
Unformatted text preview: to DNA marker polymorphisms Aa and Bb and to map between them. Clearly, in this family the mutant disease gene is present on the chromosome which happens to have alleles A and B on it. [Remember that Aa and Bb have nothing whatsoever to do with the disease, they are simply two bits of the genome which are polymorphic and which are within about a million basepairs of the disease gene.] The unborn baby can be tested to see which alleles it has inherited from its father at the two marker loci. If it has inherited A and B then it almost certainly has also inherited the disease mutation....
View Full Document
- Fall '10