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Genes in populations - Genes in populations One aspect of...

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Genes in populations One aspect of clinical genetics which makes it somewhat different to other branches of medicine is that results affecting one individual have ramifications extending to both the close family and to more distant relatives. But this is seen also in reverse; our ability to make predictive diagnoses of risk of affected offspring in a marriage will depend on our knowledge not just of the immediate families from which prospective parents are drawn but also of the populations. why do genetic diseases vary in frequency between different populations? founder effect Some genetic diseases are present at a much higher frequency in one population rather than another. For instance in the Boer population of South Africa the disease porphyria variegata is much more common than in either the Dutch population from whom the Boers are descended or the surrounding African populations. This interesting disease (which is an example of haploinsufficiency ) is familiar to those of
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