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Unformatted text preview: the tuberous sclerosis gene TSC1 on chromosome 9q34. Science 277:805-808, 1997.) . • Also, even before a gene is identified, if it can be mapped with respect to other genes or to anonymous segments of DNA (known as markers or marker loci ), then information gained from studying the linked loci can be used to deduce, for instance, whether or not a person is a carrier of a mutant gene or to give antenatal diagnosis as to whether an embryo is affected with the disease. The mathematics of linkage analysis can be frightening. However, the fundamentals of the subject are easy to grasp particularly if we start by studying experimental organisms in which we can set up those crosses which we need. Later on we must consider how to make the same type of measurements in humans whose "crosses" cannot be experimentally manipulated but where we must make deductions from families in which genetic diseases (or interesting variants) are present....
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This note was uploaded on 11/22/2011 for the course CHEMISTRY CHM1025 taught by Professor Laurachoudry during the Fall '10 term at Broward College.
- Fall '10