PROSITE patterns and rules

PROSITE patterns and rules - PROSITE patterns and rules The...

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PROSITE patterns and rules The PROSITE database has already been mentioned in this course . It was initiated and is maintained by Amos Bairoch and colleagues, now at the Swiss Institute of Bioinformatics . It is based on the proteins sequences in SWISS-PROT. It aims at describing characteristic patterns for some domain families using regular expressions , and contains about 1400 patterns, rules and profile/matrices. It is being maintained, but it is fair to say that it has been superceded in practical terms by other search methods and databases, such as Pfam (mentioned before , and discussed later ). PROSITE makes a distinction between patterns and rules, which are both described by regular expressions: A pattern is intended to capture the characteristic fingerprint of a protein domain family. A rule , on the other hand, is intended to highlight features in a protein sequence that does not necessarily have anything to do with a specific protein family. For example, potential glycosylation sites and phosphorylation sites can
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This note was uploaded on 11/22/2011 for the course CHEMISTRY CHM1025 taught by Professor Laurachoudry during the Fall '10 term at Broward College.

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PROSITE patterns and rules - PROSITE patterns and rules The...

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