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Unformatted text preview: approaches. It has some important drawbacks: If the probe sequence contains a strongly conserved domain, then the profile may be weighted towards it and away from the rest of the sequence as the iterations are performed. There is a danger that one misses weak homologies for other parts in the sequence than the strongly conserved domain. Of course, this may happen with other methods as well. A particular problem is posed by the so-called low-complexity regions in proteins (typically Gln, Ser, Thr and Pro-rich regions): these regions should be masked out, or the search will likely just try to pick up other proteins that contain this kind of sequence, which is almost certainly not what one wants....
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This note was uploaded on 11/22/2011 for the course CHEMISTRY CHM1025 taught by Professor Laurachoudry during the Fall '10 term at Broward College.
- Fall '10