Ras signalling - Ras signalling The protein Ras p21 (also...

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Ras signalling The protein Ras p21 (also called cH-ras p21) was discovered in the early 1980's as an oncogene , i.e. a gene that was mutated in many tumours, and which presumably must be involved in making cells become cancerous, or keeping them in a cancerous state. An immense amount of research has gone into characterization of these oncogenes, and one large group of them have turned out to be genes that participate in the regulation of cell growth and division. In the beginning of the 1990's, the growth regulation pathway which Ras p21 is a central part of was unravelled. It turns out that Ras p21 is part of a signalling cascade that also contains the proteins Shc, Grb2, SOS, GAP, Raf-1, MEK, ERK, and others. The purpose of the cascade is to transduce a signal from a growth-factor receptor in the cell membrane (there are several different ones) to the transcriptional regulation of genes in the nucleus that control cellular growth and division. In the image below (from the SPAD
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This note was uploaded on 11/22/2011 for the course CHEMISTRY CHM1025 taught by Professor Laurachoudry during the Fall '10 term at Broward College.

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Ras signalling - Ras signalling The protein Ras p21 (also...

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