{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

Real exceptions - (a common autosomal recessive disease...

Info icon This preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
Real exceptions mitochondrial inheritance The human mitochondrion has a small circular genome of 16,569 bp which is remarkably crowded. It is inherited only through the egg, sperm mitochondria never contribute to the zygote population of mitochondria. There are relatively few human genetic diseases caused by mitochondrial mutations but, because of their maternal transmission, they have a very distinctive pattern of inheritance. A mitochondrial inheritance pedigree All the children of an affected female but none of the children of an affected male will inherit the disease. uniparental disomy Although it is not possible to make a viable human embryo with two complete haploid sets of chromosomes from the same sex parent it is sometimes possible that both copies of a single chromosome may be inherited from the same parent (along with no copies of the corresponding chromosome from the other parent.) Rare cases of cystic fibrosis
Image of page 1
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: (a common autosomal recessive disease) have occurred in which one parent was a heterozygous carrier of the disease but the second parent had two wild type alleles. The child had received two copies of the mutant chromosome 7 from the carrier parent and no chromosome 7 from the unaffected parent. • linkage When two genes are close together on the same chromosome they tend to be inherited together because of the mechanics of chromosome segregation at meiosis. This means that they do not obey the law of independent assortment. The further apart the genes are the more opportunity there will be for a chiasma to occur between them. When they get so far apart that there is always a chiasma between them then they are inherited independently. The frequency with which the genes are separated at miosis can be measured and is the basis for the construction of genetic linkage maps (of which, more in lectures 8 & 9 )....
View Full Document

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern