Regular expressions - Regular expressions A multiple...

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Regular expressions A multiple alignment is very useful for a lot of different analysis, such as identifying patterns in the sequence that have some connection with the structure and/or the function of the protein domain. However, a large multiple alignment is difficult to handle, and we may want to condense the information in it down to the bare minimum. One way of doing that is to extract an explicit description of the pattern of conserved residues that we can identify in a multiple alignment. How can we represent a pattern of residues as found in a multiple alignment? And how can we use such a pattern to search for it in other protein sequences? Computer sciencists have devised a formalism to describe the kind of patterns we need: regular expressions (svenska: "reguljära uttryck"). Sometimes the term is abbreviated to regexp . Regular expressions can be used to describe languages of a particular, restricted kind. Ordinary human languages do not fall into this category; they are too complex. In our case, let us view the sequence of a protein (or DNA) as a sentence in a specific, small language. We can then define a particular regular expression (also called a grammar) that fits the given protein sequence. This regexp can then be used to test other sequences, to see whether they fit the pattern or not. It is essential to understand that
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This note was uploaded on 11/22/2011 for the course CHEMISTRY CHM1025 taught by Professor Laurachoudry during the Fall '10 term at Broward College.

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Regular expressions - Regular expressions A multiple...

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