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The Cell Cycle - Mitosis The act of mitosis can be...

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The Cell Cycle Within a tissue which is growing individual cells each go through a regular pattern of growth and division known as the cell cycle. There are many interesting features of the cell cycle from, for instance, a cancer biologist's viewpoint, concerned with the regulation of cell division. Cancer is, after all, a disease of unregulated cell division. From our perspective as geneticists we can take a simplified view of the process and concentrate solely on that part of the cycle which actually takes the least time, the mitotic division. Interphase Into this phase we can lump all the important events which we are not going to consider. During this phase, the cell nucleus is full of diffuse staining chromatin , DNA synthesis takes place (by semi conservative DNA replication), RNA and protein synthesis occurs and the cell doubles in size.
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Unformatted text preview: Mitosis The act of mitosis can be conveniently divided into four phases. prophase • The replicated chromosomes become visible and can be seen to be comprised of two sister chromatids still joined together at the centromere , • the nuclear membrane breaks down, • centrioles move to opposite poles • and the spindle forms between them. metaphase • The chromosomes attach to the spindle by their kinetochores (which are part of the centromere structure). • The chromosomes are now at their most condensed. • They line up at the equator of the spindle. anaphase • The centromeres divide • the chromosomes are pulled apart to the two poles by contracting spindle fibres. telophase • Nuclear membranes reform • the chromosomes decondense. • The daughter cells return to interphase....
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