The genomes - The genomes: why? A genome is the completely...

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The genomes: why? A genome is the completely (or almost completely) determined DNA sequence of the genetic material (chromosomes as well as any plasmids, mitochondrial DNA, etc) of an organism. The word is somewhat of a misnomer: a genome isn't the same as 'all genes', it is rather 'sequence of all DNA' wherein all genes can be found. The first genome of a free living organism (viruses aside) was that of Haemophilus influenzae published in 1995 (Fleischmann et al, Science (1995) vol 269, pp 496- 512 ). Why are complete genomes interesting? The most basic answer to that question is that we want to know the complete set of genes that an organism has. The genome of an organismis in a certain sense the blueprint for that organism. Many observations and experiments in biology involve mutants and mutations, and knowing the complete set of genes for an organism can help with the analysis. For example, we may want to be sure that a knocked-out gene does not have a backup copy somewhere in the
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This note was uploaded on 11/22/2011 for the course CHEMISTRY CHM1025 taught by Professor Laurachoudry during the Fall '10 term at Broward College.

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