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Unformatted text preview: and D9S150 because individuals were found who had inherited only part of the chromosome due to genetic recombination in the formation of the gamete from their affected parent. • Most areas of the human genome have now been cloned. Clones covering the minimum area are identified and used to find all the genes in the area. • Mutations in these genes are sought in the affected patients. Hopefully this should lead to that "Eureka" moment. • As more and more of the genome is sequenced already, several of these steps may be bypassed. It may be possible to jump directly from the definition of the genetic interval within which the gene must lie to the mutation screen. As well as the TSC1 success story above there have been many other examples of successful identification of disease genes based solely, or almost solely, on positional information. The classic example is the cystic fibrosis gene CFTR ....
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This note was uploaded on 11/22/2011 for the course CHEMISTRY CHM1025 taught by Professor Laurachoudry during the Fall '10 term at Broward College.
- Fall '10