The story of Queen Victoria Haemophilia is sometimes referred to as the Royal disease. Queen Victoria had no ancestors with the condition but soon after the birth of her eighth child, Leopold, in 1853 it became evident that he had haemophilia. Queen Victoria was thus an example of how the condition can arise as a spontaneous mutation. Leopold's medical condition was reported in the British Medical Journal in 1868, and it is clear that he was troubled by bleeds occurring at least once a month. He died at the age of 31 in 1884 from intracerebral haemorrhage after a fall. Leopold had married two years before his death. His daughter, Alice, was an obligate carrier and also went on to have a haemophilic son. Rupert, Viscount Trematon, was born in 1907 and died at the age of 21, also from an intracerebal haemorrhage. It also subsequently transpired that two of Queen Victoria's own daughters, Alice and Beatrice, were carriers of haemophilia. The condition was transmitted through them to several Royal families in Europe, including Spain and Russia. Perhaps the most
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This note was uploaded on 11/22/2011 for the course CHEMISTRY CHM1025 taught by Professor Laurachoudry during the Fall '10 term at Broward College.