Unformatted text preview: of a chromosome occurs at a frequency of 1 in 100 cell divisions). Patients will show multiple tumours caused by many such second events. There are many examples of inherited genes of this type such as retinoblastoma and the breast cancer genes BRCA1 andBRCA2 . The concept of the first (rare) event which must be followed by a second (much more frequent) event to initiate a cancer was first put forward by Knudsen in 1972....
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This note was uploaded on 11/22/2011 for the course CHEMISTRY CHM1025 taught by Professor Laurachoudry during the Fall '10 term at Broward College.
- Fall '10