types of genetic - types of genetic'marker Any genetic...

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types of genetic 'marker' Any genetic variation can be studied and it is not necessary that the objects being measured in a linkage study are genes. Any polymorphic piece of DNA can be studied. Examples include Restriction Fragment Length Polymorphisms (RFLPs) caused by the presence or absence of a restriction site. The two alleles can be distinguished from each other by Southern blotting . Variable Numbers of Tandem Repeats (VNTRs) which can include o mini satellite repeats (as discovered by Sir Alec Jeffreys) in which the alleles may be identified by Southern blotting or by PCR . o microsatellite repeats, (di, tri and tetra nucleotide repeats) in which the alleles are almost always identified by PCR . All VNTRs have multiple alleles which is a good thing for genetic mapping, since it makes it more likely that you will be able to distinguish between both alleles in any person whom you wish to study. The use of Lod scores
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This note was uploaded on 11/22/2011 for the course CHEMISTRY CHM1025 taught by Professor Laurachoudry during the Fall '10 term at Broward College.

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types of genetic - types of genetic'marker Any genetic...

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