Mutation - Mutation HigherBiology Mutation 1 2 material =...

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Mutation Higher Biology
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Mutation Change in structure or amount of an organism’s genetic  material Change in genotype produces change in phenotype =  mutant 2 types of mutation 1. Chromosome mutation 2. Change in structure of one chromosome
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Chromosome mutations Change in chromosome number 1. Non-disjunction in meiosis 2. Non-disjunction of sex chromosomes 3. Complete non-disjunction and polyploidy
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Non-disjunction  during meiosis Spindle fibre fails during meiosis Members of one pair of homologous chromosomes fail to  become separated 2 gametes receive extra copy of affected chromosome 2 gametes lack that chromosome
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Down’s Syndrome Non-disjunction in chromosome 21 Occurs in human egg mother cell One or more abnormal eggs formed (n = 24) Fertilised by normal sperm (n = 23) Formation of abnormal zygote (2n = 47)
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Non dis-junction of sex chromosomes
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