Cocaine

Cocaine - Chemical Reactions in the Drug World Synthesis...

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Chemical Reactions in the Drug World Synthesis and Biological Actions of Cocaine
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Overview Cocaine Synthesis and Extraction Affects of Cocaine on the human body Cocaine in the media
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Cocaine Extraction Coca leaves are stripped from the plant and crushed, chopped, and/or pounded mixed with a solution of alcohol, gasoline, kerosene, or some other solvent that will remove the cocaine from the leaves.
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2. Acid-Base Neutralization 1. Dissolve using solvents Extraction and Purification 3. Oxidation to ↑ purity colour Δ indicates end rxn
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Cocaine Purification The resulting liquid contains unpurified cocaine alkaloids and waxy material from the leaves. The waxy material is removed by heating and cooling the mixture, which solidifies the unwanted wax. cocaine alkaloids are isolated from the liquid using acid and base mixtures. The removed alkaloids are then treated with kerosene. The kerosene is removed and crystals of crude cocaine are left at the bottom of the tank. The crystals are dissolved in methyl alcohol .
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Cont’d Purification and Conversion 4. Removes precipitate from last rxn 5. acid-base neutralization 6. Dissolve in solvent 7. Dissolve in solvent crystallizes
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Cocaine Purification They are then recrystallized and dissolved in sulfuric acid, which results in cocaine that is about 60% pure. cocaine at this point is freebase cocaine (crack). When a person freebases cocaine, or makes crack, they are reversing what is done in the next process.
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Cocaine Conversion freebase is converted cocaine hydrochloride (a salt). The reasons for the conversion 1 ) left in this form for long it would lose its potency
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This note was uploaded on 11/23/2011 for the course BIO 100 taught by Professor Robinson during the Fall '08 term at BYU.

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Cocaine - Chemical Reactions in the Drug World Synthesis...

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