113lecture2506

113lecture2506 - BIOLOGY 113 - MICROBIOLOGY Lecture 25:...

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BIOLOGY 113 - MICROBIOLOGY Lecture 25: Specific Host Defenses - T cells and cell-mediated immunity T cells are the key component of cell-mediated immunity - Like B cells, T cells develop from stem cells in bone marrow - Developing T cells migrate to and mature in the thymus - Fully mature T cells then migrate to the various lymphoid tissues where, again like B cells, they encounter foreign antigens When T cells encounter antigen, they are stimulated to proliferate into various types of effector T cells (Tortora et al., Table 17.3) - T cells recognize antigen, as peptides, in close association with cell surface proteins of the major histocompatibility complex (MHC) - Antigen/MHC complexes are recognized by T-cell receptors (TCRs) on the surface of T cells; like immunoglobulins, TCRs have constant and variable domains - The different types of effector T cells can be distinguished by characteristic surface proteins - Helper T cells (T H ) regulate the activities of other cells involved in immune response
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This note was uploaded on 11/24/2011 for the course BIO 113 taught by Professor Staff during the Fall '09 term at Rutgers.

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113lecture2506 - BIOLOGY 113 - MICROBIOLOGY Lecture 25:...

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