113lecture3106 - BIOLOGY 113 - MICROBIOLOGY Lecture 31:...

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BIOLOGY 113 - MICROBIOLOGY Lecture 31: Microbial Diseases of the Cardiovascular System - Bacterial infections Microbial diseases of the cardiovascular system include those in which a pathogen invades and is distributed through tissues of the cardiovascular system and/or the lymphatic system - The cardiovascular system consists of the heart, blood and blood vessels - The lymphatic system consists of lymph, lymph vessels, and lymphatic tissues = Because lymphatic vessels are relatively permeable and drain the interstitial fluid (which becomes lymph) from tissues throughout the body, they readily pick up microorganisms and their products = At various points, lymph flows through lymph nodes (Tortora et al., Figure 23.2, inset B), where microorganisms and their products are phagocytosed by macrophages, which present antigens to lymphocytes = On occasion, the accumulation of microbial material and the proliferation of lymphocytes leads to enlargement of the lymph nodes, a classic infectious disease symptom. Septicemia is the proliferation of bacteria in blood - The organisms most often associated with septicemia are Gram-negative bacteria, such as Escherichia coli , Serratia marcescens and Pseudomonas aeruginosa - A potentially lethal consequence of septicemia is septic shock resulting from release of endotoxin from the invading bacteria - Many cases of septicemia are of nosocomial origin, where bacteria that are normally incapable of invading the cardiovascular system are introduced by medical procedures - Puerperal sepsis , or "childbirth fever", results from septicemia associated with childbirth or abortion = The most frequent pathogen associated with puerperal sepsis is Streptococcus pyogenes , a ß- hemolytic streptococcus = Infection of the uterus progresses to peritonitis and then to septicemia = Once quite common, the incidence of puerperal sepsis was reduced dramatically by adoption
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This note was uploaded on 11/24/2011 for the course BIO 113 taught by Professor Staff during the Fall '09 term at Rutgers.

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113lecture3106 - BIOLOGY 113 - MICROBIOLOGY Lecture 31:...

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