113lecture3106slides - Microbial Diseases of the...

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Microbial Diseases of the Cardiovascular System Bacterial Infections The cardiovascular system The lymphatic system Lymphatic vessels drain interstitial fluids from tissues Lymph nodes contain lymphocytes and antigen-presenting cells
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Septicemia - Proliferation of bacteria in the bloodstream • Release of microbial products may lead to septic shock • Often nosocomial • Gram-negative sepsis - Due to release of lipopolysaccharide • Gram-positive sepsis - Enterococcus faecalis, E. faecium, Streptococcus agalactiae Puerperal sepsis – Infection of the uterus, typically by Streptococcus pyogenes, leading to peritonitis and septicemia – Control of puerperal sepsis was a significant outcome of antisepsis in delivery Bacterial Endocarditis • Colonization of the endocardium Subacute bacterial endocarditis – Typically infection with α -hemolytic streptococci – Risk enhanced by pre-existing damage or congenital valve defects Acute bacterial endocarditis Rheumatic fever - Autoimmune damage associated with Streptococcus pyogenes
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113lecture3106slides - Microbial Diseases of the...

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