113lecture3206

113lecture3206 - BIOLOGY 113 - MICROBIOLOGY Lecture 32:...

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BIOLOGY 113 - MICROBIOLOGY Lecture 32: Microbial Diseases of the Cardiovascular System - Viral, protozoan and helminthic infections Myocarditis , inflammation of the myocardium (heart muscle), is usually due to infection with a virus of the coxsackievirus group - The virus may spread to the heart from the gastrointestinal tract or respiratory tract via cardiovascular or lymphatic vessels - Myocarditis of the newborn is often fatal Worldwide, infection with Epstein-Barr (EB) virus , one of the herpesviruses, is extremely common - In less developed regions, 90% of children over four years of age have antibodies to EB virus, indicating prior infection; childhood EB infections are usually asymptomatic - If infection is delayed until young adulthood (as is often the case in the United States), infectious mononucleosis results = General weakness, swollen lymph nodes, and an enlarged spleen are the characteristic symptoms of "mono" = Acquisition of the virus is usually from saliva; the virus multiplies in the parotid glands = The name "mononuclosis" (and some of the symptoms) comes from the tendency of EB virus to transform B cells, leading to proliferation of unusual plasma cells, which can be detected in blood samples - EB virus has been proposed as a candidate for the etiologic agent of chronic fatigue syndrome
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113lecture3206 - BIOLOGY 113 - MICROBIOLOGY Lecture 32:...

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