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113lecture3406slides - Microbial Diseases of the Lower...

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Microbial Diseases of the Lower Respiratory Tract Pertussis Bordetella pertussis Tracheal exotoxin interferes with mucociliary escalator, leading to paroxysmal stage Greatest danger to young children; adult infection is often milder Controlled by vaccination Tuberculosis Mycobacterium tuberculosis Acid-fast cell wall Promotes environmental survival Resists host defense • Intracellular multiplication in macrophages
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Pathogenesis of tuberculosis Infected macrophages may be activated, leading to destruction of the mycobacteria The host may isolate infected macrophages in a tubercle This may lead to the host containing the infection for long periods However, the bacteria may eventually break out, leading to miliary tuberculosis
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Control of tuberculosis Tuberculosis is a disease of poverty. Nutrition is an important factor in control. Bacille Calmette Guerin , BCG, an attenuated vaccine, is of limited value Drug therapy
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