113lecture3406slides

113lecture3406slides - Microbial Diseases of the Lower...

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Unformatted text preview: Microbial Diseases of the Lower Respiratory Tract Pertussis • Bordetella pertussis • Tracheal exotoxin interferes with mucociliary escalator, leading to paroxysmal stage • Greatest danger to young children; adult infection is often milder • Controlled by vaccination Tuberculosis • Mycobacterium tuberculosis • Acid-fast cell wall – Promotes environmental survival – Resists host defense • Intracellular multiplication in macrophages Pathogenesis of tuberculosis • Infected macrophages may be activated, leading to destruction of the mycobacteria • The host may isolate infected macrophages in a tubercle • This may lead to the host containing the infection for long periods • However, the bacteria may eventually break out, leading to miliary tuberculosis Control of tuberculosis • Tuberculosis is a disease of poverty. Nutrition is an important factor in control. • Bacille Calmette Guerin , BCG, an attenuated vaccine, is of limited value • Drug therapy – May require multiple drugs for extended...
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This note was uploaded on 11/24/2011 for the course BIO 113 taught by Professor Staff during the Fall '09 term at Rutgers.

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113lecture3406slides - Microbial Diseases of the Lower...

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