lecture 3 Cell biology and Differential gene expression

lecture 3 Cell biology and Differential gene expression -...

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1 The Role of Cells and Genes in Development Molecular Biology of the Cell
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2 The Cells and It’s Organelles
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3 Epithelial cells verses Mesenchymal cells
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4 The Mechanisms of Cell Differentiation How different genes from the same genetic repertoire are activated or repressed at different times and places to cause cells to become different from one another
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5 The regulation of gene expression can be accomplished at several levels: Differential gene transcription: DNA nRNA Selective nuclear RNA processing: nRNA mRNA Selective mRNA translation mRNA Protein Differential protein modification Active protein Inactive Protein
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6 Differential gene transcription: Eukaryotic genes are contained within a “tight” complex of DNA and protein called chromatin which must be “loosened” to allow for transcription DNA RNA
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7 This H1-dependent confirmation prevents the access of the transcription factors and RNA polymerases to the genes Chromatin
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8 Anatomy of a gene Eukaryotic genes are not co-linear with the proteins they encode. Intervening sequences called introns are between the regions of DNA coding for protein called exons. * *
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9 The promoter region is where RNA polymerase binds for subsequent initiation of transcription * Anatomy of a gene
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The transcription initiation site is also called the cap sequence because it represents the 5’ end of the RNA which will be “capped” with modified nucleotides soon after it is transcribed, needed to bind To ribosomes for translation. * Anatomy of a gene
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This note was uploaded on 11/26/2011 for the course BIO 361 taught by Professor Dr.bjgrubb during the Fall '10 term at N.C. A&T.

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lecture 3 Cell biology and Differential gene expression -...

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