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lecture29_SexDeterminationpart2Hormonal

lecture29_SexDeterminationpart2Hormonal - Sex...

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1 Sex Determination (Hormonal) Part II
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2 Two phases of sex determination: A. Primary sex determination- determination of the gonads. B. Secondary sex determination- determination of bodily phenotype outside of the gonads. Males: penis, prostate gland, seminal vesicles, musculature, vocal cartilage, sex-specific size, and sex-specific ducts. Females: uterus, vagina, cervix and sex-specific ducts and body size.
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3 Gonad development
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4 Primary sex determination in mammals is controlled by Sex linked genes and Autosomal genes
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5
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6 The Sox 9 and Sf1 regulate the Amh gene to express the Anti-Mullerian duct Hormone
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7
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8 The Mullerian duct will degenerate in males. The Wolffian duct forms the epididymis and vas deferens Figure 27.4
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9 The Mullerian duct forms the Uterus and oviduct in females. The Wolffian duct degenerates. Figure 27.5
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10 Synthesis of Steroid hormones Figure 27.2
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11 Anti- Müllerian Duct Hormone (AMH) Also an important factor for normal development of male secondary sex structures.
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