Metabolism- Remaining Slides

Metabolism- Remaining Slides - III Anabolic Pathways...

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Unformatted text preview: III. Anabolic Pathways “Biosynthesis” • Making glucose, TG, amino acids A. Carbohydrate Synthesis 1. Gluconeogenesis • Liver (90%) • Kidneys (10%) • From glycerol, lactate, glucogenic amino acids converted to pyruvate py pyruvate glucose requires ATP, NADH 1 A. Carbohydrate Synthesis 2. Glycogenesis • Liver, muscle • Glucose(s) glycogen 2 B. Triglyceride Synthesis Lipogenesis • Requires ATP • From fatty acids amino acids alcohol acetyl CoA fatty acids • Triglyceride assembly = fatty acids + glycerol stored in adipose tissue • NADPH provides energy C. Nonessential AA Synthesis Transamination • From pyruvate and compounds from glycolysis and citric acid cycle pyruvate alanine -ketoglutarate glutamate oxaloacetate aspartate 3 C. Nonessential AA Synthesis Other processes • Amidation • Hydroxylation • Multi-step reactions IV. Feasting Excess Intake of Energy Nutrients Increase Stores • Glycogen from glucose • Fat from TG, AA, glucose TG AA glucose efficiency differs Weight Gain 4 V. Fasting Inadequate Intake of Energy Nutrients • Initial use of glycogen and fat • Prolonged fasting body fat = primary fuel source ketosis use body protein for glucose, energy Weight Loss 5 ...
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This note was uploaded on 11/27/2011 for the course HUN 2201 taught by Professor Sitren during the Fall '08 term at University of Florida.

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Metabolism- Remaining Slides - III Anabolic Pathways...

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