Extra Credit Quiz ONE

Extra Credit Quiz ONE - MCB 2000 MICROBIOLOGY Extra Credit...

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MCB 2000 MICROBIOLOGY Extra Credit Quiz ONE HOW MICROBES CAUSE DISEASE The universal principle of molecular recognition. Biological molecules interact by recognizing and binding with one another in a highly specific manner. Pairs of molecules that interact in this way are called RECEPTORS or BINDING SITES and LIGANDS respectively. Specific regions of atoms (molecular domains) on a receptor molecule have the characteristic of binding or attaching (docking) specifically to unique molecular domains on specific ligands. Following this binding something happens depending on the system involved. In this chapter you will learn how microbes produce disease by recognizing their specific hosts and by producing substances that interact specifically with host receptors to cause disease. Permission to use this cartoon was granted by Sigma Chemical Co . GOALS OF DISEASE SECTION The learning goals of this section are:
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To understand the nature of disease, particularly infectious disease. To learn the ways bacteria have of invading and producing the disease state. INTRODUCTION During my all-too-brief lifetime I have seen us go from a state of virtual defenselessness against many infectious bacteria and viruses, where, outside of immunization, prayer, occasional surgery and TLC (tender-loving-care), there was little medically we could do about bacterial infections, to an era of optimistic arrogance where we claimed VICTORY over ALL BACTERIAL INFECTIONS , to the recognition today that this battle is going to go on for the indefinite future and that there is some question now as to the eventual OUTCOME. In spite of our considerable knowledge about diseases most people in undeveloped countries still die of the same infectious diseases that killed their ancestors 10,000 years ago and that are mostly PREVENTABLE . The WHO estimates that approximately 15 million CHILDREN die each year of preventable infectious disease. An infectious disease agent must be able to grow on or in a host and it must do harm to that host. Every infectious disease is characterized by the SYMPTOMS produced in the average victim of that infectious disease. These symptoms, referred to as the CLINICAL SYMPTOMS , are used by physicians and health care personnel to identify a particular infectious disease or group of infectious diseases. For example, one set of symptoms identify common upper respiratory diseases (colds). However, the mumps virus has a UNIQUE set of symptoms that are used in diagnosing this particular infectious agent. That is, a single pathogen may produce a clear set of symptoms that allows its easy recognition, whereas a set of identical symptoms (e.g. the "runs", colds, pneumonia) may be produced by a number of different infectious disease agents. Finally, some infectious disease agents cause a variety of different symptoms in different hosts of the same species; AIDS and tuberculosis are two such examples. In describing an infectious disease the agent is identified, if known, the symptoms are
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This note was uploaded on 11/27/2011 for the course MCB 2000 taught by Professor Staff during the Fall '08 term at University of Florida.

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Extra Credit Quiz ONE - MCB 2000 MICROBIOLOGY Extra Credit...

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