fattyametable

fattyametable - Fatty Acid b-Oxidation Stage Enzyme...

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Fatty Acid b -Oxidation Stage Enzyme Non-Fatty Acid Reactants Products Comments Fatty Acid Release triacylglycerol lipase H2O Activation acyl CoA synthetase (thiokinase) ATP, CoASH AMP, PPi subsequent PPi hydrolysis pulls reaction Transport into Mitochondria carnitine acyltransferase I carnitine CoASH carnitine acyltransferase II CoASH carnitine links acyl to carnitine by ester linkage for transport replaces carnitine with CoA inside the mitochondria acyl CoA dehydrogenase FAD FADH2 3-hydroxy acyl CoA dehydrogenase 3-ketoacyl thiolase NAD+ NADH b-oxidation hormone control, phosphorylated enzyme is active form Different forms of enzyme for different acyl lengths CoASH palmitate + 8 CoASH + ATP + 7 FAD + 7 NAD+ + 7 H2O ’ 8 acetyl CoA + AMP + 2 Pi + 7 FADH2 + 7 NADH/H+ Fatty Acid Synthesis (Multifunctional enzyme dimer in animals = fatty acid synthase) Stage Acetyl CoA activation Elongation Termination Enzyme acetyl CoA carboxylase Non-Fatty Acid Reactants Products HCO3-, ATP 3-ketoacyl-ACP synthase 3-ketoacyl-ACP reductase NADPH Enoyl-ACP reductase NADPH thioesterase H2O ADP, Pi Comments biotin coenzyme, allosteric control (citrate +); hormone control, unphosphorylated enzyme is active polymerized form CO2,ACPSH NADP+ NADP+ releases palmitate from synthase 8 acetyl CoA + 7 ATP + 14 NADPH/H+ ’ palmitate + 8 CoASH + 7 ADP + 7 Pi + 14 NADP+ + 6 H2O ...
View Full Document

{[ snackBarMessage ]}

Ask a homework question - tutors are online