fattyametable - Fatty Acid b-Oxidation Stage Enzyme...

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Unformatted text preview: Fatty Acid b -Oxidation Stage Enzyme Non-Fatty Acid Reactants Products Comments Fatty Acid Release triacylglycerol lipase H2O Activation acyl CoA synthetase (thiokinase) ATP, CoASH AMP, PPi subsequent PPi hydrolysis pulls reaction Transport into Mitochondria carnitine acyltransferase I carnitine CoASH carnitine acyltransferase II CoASH carnitine links acyl to carnitine by ester linkage for transport replaces carnitine with CoA inside the mitochondria acyl CoA dehydrogenase FAD FADH2 3-hydroxy acyl CoA dehydrogenase 3-ketoacyl thiolase NAD+ NADH b-oxidation hormone control, phosphorylated enzyme is active form Different forms of enzyme for different acyl lengths CoASH palmitate + 8 CoASH + ATP + 7 FAD + 7 NAD+ + 7 H2O ’ 8 acetyl CoA + AMP + 2 Pi + 7 FADH2 + 7 NADH/H+ Fatty Acid Synthesis (Multifunctional enzyme dimer in animals = fatty acid synthase) Stage Acetyl CoA activation Elongation Termination Enzyme acetyl CoA carboxylase Non-Fatty Acid Reactants Products HCO3-, ATP 3-ketoacyl-ACP synthase 3-ketoacyl-ACP reductase NADPH Enoyl-ACP reductase NADPH thioesterase H2O ADP, Pi Comments biotin coenzyme, allosteric control (citrate +); hormone control, unphosphorylated enzyme is active polymerized form CO2,ACPSH NADP+ NADP+ releases palmitate from synthase 8 acetyl CoA + 7 ATP + 14 NADPH/H+ ’ palmitate + 8 CoASH + 7 ADP + 7 Pi + 14 NADP+ + 6 H2O ...
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