Understanding Cortical Folding Patterns in Development, Aging and Disease Monica K. Hurdal Department of Mathematics Florida State University Email: [email protected]There is controversy and debate regarding the mechanisms involved in cortical fold formation. Current cortical morphogenesis theories describe folding using tension-based or cellular-based arguments. Modeling and understanding cortical folding pattern formation is important for quantifying cortical development. Hypotheses concerning brain growth and development can lead to quantitative biomarkers of normal and abnormal brain growth. Cortical folding malformations have been related to a number of diseases, including autism and schizophrenia. In this seminar I will present a biomathematical model for cortical folding pattern formation in the brain. This model takes into account global cortex characteristics and can be used to model folds across species as well as specific diseases involving cortical pattern malformations that can occur in human brain folding patterns, such as
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Florida State University, Department of Mathematics, cortical folding pattern, Monica K. Hurdal