lec19_04202007_w - 10.37 Chemical and Biological Reaction...

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10.37 Chemical and Biological Reaction Engineering, Spring 2007 Prof. K. Dane Wittrup Lecture 19: Oxygen transfer in fermentors This lecture covers: Applications of gas-liquid transport with reaction Gas-liquid mass transfer in bioreactors Microbial cells often grown aerobically in stirred tank reactors -oxygen supply is often limiting X D.O. μ X X X X X X X X X critical value 0.01 mM Figure 1. μ vs dissolved oxygen. D.O. = dissolved oxygen Equilibrium solubility of O 2 1 mM O 2 2 3 4 1 cell bubble Figure 2. Oxygen pathway. 1) Diffusion across stagnate gas film 2) Absorption 3) Stagnate liquid layer (rate-limiting step) 4) Diffusion and convection Cite as: K. Dane Wittrup, course materials for 10.37 Chemical and Biological Reaction Engineering, Spring 2007. MIT OpenCourseWare (http://ocw.mit.edu), Massachusetts Institute of Technology. Downloaded on [DD Month YYYY].
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3) O 2 flux =− kC () * [=] lO 22 C O mol area time What is the value for the interfacial area?
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lec19_04202007_w - 10.37 Chemical and Biological Reaction...

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