01a_jain - Harvard-MIT Division of Health Sciences and...

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1 Angiogenesis & Microcirculation (Lecture I) Vascular Transport (Lecture I) Interstitial and Lymphatic Transport (Lecture II) Vascular Normalization (Lecture Il) Delivery of Molecular and Cellular Medicine to Tumors Harvard-MIT Division of Health Sciences and Technology HST.525J: Tumor Pathophysiology and Transport Phenomena, Fall 2005 Course Director: Dr. Rakesh Jain
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DELIVERY OF MOLECULAR MEDICINE TO TUMORS Lecture I: Tumor Angiogenesis and Microcirculation OVERVIEW R.K. Jain, “Barriers to Drug Delivery in Solid Tumors,” Scientific American, 271:58-65 (1994). R.K. Jain, “Delivery of Molecular Medicine to Solid Tumors,” Science, 271:1079-1080 (1996). R.K. Jain, “1996 Landis Award Lecture: Delivery of Molecular and Cellular Medicine to Solid Tumors,” Microcirculation, 4:1-23 (1997). R.K. Jain, “The Next Frontier of Molecular Medicine: Delivery of Therapeutics,” Nature Medicine, 4:655-657 (1998). J.W. Baish and R.K. Jain, “Fractals and Cancer,” Cancer Research, 60: 3683-88 (2000). P. Carmeliet and R.K. Jain, “Angiogenesis in Cancer and Other Diseases,” Nature, 407: 249-257 (2000). R.K. Jain and P. Carmeliet, “Vessels of Death or Life,” Scientific American, 258: 38-45 (2001). R.K. Jain, L.L. Munn, and D. Fukumura, “Dissecting Tumor Pathophysiology using Intravital Microscopy,” Nature Reviews Cancer, 2: 266- 276 (2002). R.K. Jain, “Angiogenesis and Lymphangiogenesis in Tumors: Insights from Intravital Microscopy,” Cold Spring Harbor Symposia on Quantitative Biology (The Cardiovascular System), 67 : 239-248 (2002). R.K. Jain, “Molecular Regulation of Vessel Maturation,” Nature Medicine, 9:685-693 (2003). R.K. Jain, “Normalization of the tumor vasculature: An emerging concept in anti-angiogenic therapy”, Science 307: 58-62 (2005). R. K. Jain, “Antiangiogenic therapy of cancer: Current and emerging concepts,” Oncology (Supplement), 19: 7-16 (2005).
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2005 3 Tumor Microcirculatory Preparations T.E. Dudar and R.K. Jain, “Differential Responses of Normal and Tumor Microcirculation to Hyperthermia,” Cancer Research, 44:605-612 (1984). M. Leunig, F. Yuan, M.D. Menger, Y. Boucher, A.E. Goetz, K. Messmer and R.K. Jain, “Angiogenesis, Microvascular Architecture, Microhemodynamics, and Interstitial Fluid Pressure During Early Growth of Human Adenocarcinoma LS174T,” Cancer Research, 52:6553-6550 (1992). F. Yuan, H.A. Salehi, Y. Boucher, U. S. Vasthare, R.F. Tuma and R.K. Jain, “Vascular Permeability and Microcirculation of Gliomas and Mammary Carcinomas Transplanted in Rat and Mouse Cranial Windows,” Cancer Research, 54:4564-4568 (1994). TUMOR MODELS Isolated Tumor Preparation P.M. Gullino, “Techniques in Tumor Pathophysiology,” Methods in Cancer Research , 5:45-92 (1970). E.M. Sevick and R.K. Jain, “Geometric Resistance to Blood Flow in Solid Tumors Perfused Ex Vivo: Effects of Tumor Size and Perfusion Pressure,” Cancer Research , 49:3506-3512 (1989). P.E.G. Kristjansen, S. Roberge, I. Lee and R.K. Jain, “Tissue-isolated Human Tumor Xenografts in Athymic Nude Mice,” Microvascular Research , 48:389-402 (1994).
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01a_jain - Harvard-MIT Division of Health Sciences and...

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