exam_prep - • Norbornane: methine bridgehead 3 J to exo...

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Chemistry 5.46 Organic Structure Determination Major Points Summary
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Entry points based on… • Chemical shifts • Integrals and intensities • J-couplings and multiplet analysis
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HMQC/HSQC • Identifies methyl 13 C’s • Pairs methylene 1 H’s with Δδ ’s on 13 C’s • Reveals methine 1 H/ 13 C pairs
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Miscellaneous • 2-D plotting: t 1 ridges and snow-capped peaks • 2-D plotting: threshold and noise floor • HMBC: consequence of no X-decoupling
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Unformatted text preview: • Norbornane: methine bridgehead 3 J to exo is bigger than to endo gCOSY • 3 J HH ’s most useful • 4 J HH ’s and 5 J HH ’s should be plausible • Helps improve 1 H δ determinations HMBC • 2 J HC ’s stronger through sp 3 and than sp 2 13 C’s • 3 J HC ’s 0-12+ Hz as function of dihedral angle • 4 J HC ’s and 5 J HC ’s found in rigid systems...
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This note was uploaded on 11/27/2011 for the course CHEMICAL E 20.410j taught by Professor Rogerd.kamm during the Spring '03 term at MIT.

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exam_prep - • Norbornane: methine bridgehead 3 J to exo...

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