Collagen7.88J Protein FoldingProf. David GossardOctober 20, 2003
PDB AcknowledgementsThe Protein Data Bank(PDB -http://www.pdb.org/) is the single worldwide repository for the processing and distribution of 3-D biological macromolecular structure data.Berman, H. M., J. Westbrook, Z. Feng, G.Gilliland, T. N.Bhat, H.Weissig, I. N.Shindyalov, and P. E.Bourne. “The Protein DataBank.”Nucleic Acids Research 28 (2000): 235-242.(PDB Advisory Notice on using materials available in the archive: http://www.pdb.org/pdb/static.do?p=general_information/about_pdb/pdb_advisory.html)PDB molecules and citations used in the “Collagen” Lecture Notes for 7.88J - Protein FoldingPDB ID:1CGDJRNL reference:Bella, J., M. Eaton, B. Brodsky, and H. M. Berman. “Crystal and molecular structure of a collagen-like peptide at 1.9A resolution.” Science 266 (October 7, 1994):75-8.Pages: 16-17 (“Solved Structure – 1CGD”)
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Collagen~20% of all proteins in human body are collagenExtracellular matrix protein family–At least 21 different types of collagenStructural protein–Bone, tendon, cartilage, cornea, etc.Mutations in collagen responsible for–Osteogenesis imperfecta–Hereditary aortic aneurysm