lec12 (1) - MIT OpenCourseWare http:/ocw.mit.edu 7.88J...

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MIT OpenCourseWare http://ocw.mit.edu 7.88J Protein Folding Problem Fall 2007 For information about citing these materials or our Terms of Use, visit: http://ocw.mit.edu/terms .
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Collagen 7.88J Protein Folding Prof. David Gossard October 20, 2003
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PDB Acknowledgements The Protein Data Bank (PDB - http://www.pdb.org/ ) is the single worldwide repository for the processing and distribution of 3-D biological macromolecular structure data. Berman, H. M., J. Westbrook, Z. Feng, G.Gilliland, T. N.Bhat, H.Weissig, I. N.Shindyalov, and P. E.Bourne. “The Protein Data Bank.” Nucleic Acids Research 28 (2000): 235-242. (PDB Advisory Notice on using materials available in the archive: http://www.pdb.org/pdb/static.do?p=general_information/about_ pdb/pdb_advisory.html ) PDB molecules and citations used in the “Collagen” Lecture Notes for 7.88J - Protein Folding PDB ID: 1CGD JRNL reference: Bella, J., M. Eaton, B. Brodsky, and H. M. Berman. “Crystal and molecular structure of a collagen-like peptide at 1.9A resolution.” Science 266 (October 7, 1994):75-8. Pages: 16-17 (“Solved Structure – 1CGD”)
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Collagen ± ~20% of all proteins in human body are collagen ± Extracellular matrix protein family – At least 21 different types of collagen ± Structural protein – Bone, tendon, cartilage, cornea, etc. ± Mutations in collagen responsible for – Osteogenesis imperfecta – Hereditary aortic aneurysm
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Pathway ± Synthesized as longer precursors (procollagens) with globular extensions at both ends (propeptides) ± Propeptides form inter-chain disulfide bonds that align the chains prior to triple helix formation Engel , J., and D. Prockop. “The zipper-like folding of collagen triple helices and the effects of mutations that distrupt the zipper”, Annu. Rev. Biophys. Biphys. Chem 1991, 20 : 137-52.
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lec12 (1) - MIT OpenCourseWare http:/ocw.mit.edu 7.88J...

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