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Unformatted text preview: MIT OpenCourseWare http://ocw.mit.edu 5.111 Principles of Chemical Science Fall 2008 For information about citing these materials or our Terms of Use, visit: http://ocw.mit.edu/terms . 36.1 5.111 Lecture Summary #36 Review of Topics Chemical Equilibrium, Acid Base, Oxidation Reduction, Transition Metals, and Kinetics These topics represent the basic principles of how enzymes work, and one needs to understand how enzymes work to inhibit them. Inhibition of enzymes is used to treat headaches, arthritis, cancer, HIV, etc Big money for the Pharmaceutical industry Let's review these topics using methionine synthase as a case study. KINETICS Methionine synthase (MetH) is an enzyme, "a catalyst of life". It transfers a methyl group from methyltetrahydrofolate to homocysteine, generating methionine and tetrahydrofolate. Inhibition of this enzyme has been associated with neutral tube defects and heart disease. It is also a potential chemotherapeutic target....
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lecnotes36 - MIT OpenCourseWare http://ocw.mit.edu 5.111...

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