sg_vii - Massachusetts Institute of Technology 5.13:...

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Massachusetts Institute of Technology 5.13: Organic Chemistry II Fall 2003 Outline & Study Guide for Unit VII. Carbocations “Every generation of scientific men (i.e. scientists) starts where the previous generation left off; and the most advanced discoveries of one age constitute elementary axioms of the next.” –Aldous Huxley Professor George A. Olah of The University of Southern California began his Nobel lecture with this quote when he was awarded the 1994 Nobel Prize in Chemistry for “his contribution to carbocation chemistry.” Carbocationic species are intermediates in many chemical reactions carried out in the laboratory, as well as numerous reactions that take place in nature. One famous example of a carbocationic cascade reaction is the biosynthesis of cholesterol from squalene oxide. Conversion of the linear polyene to the four-ring steroid nucleus happens through a series of carbocation rearrangements. Elucidation of this extraordinary biosynthetic pathway, one of the most complex known, was accomplished by Konrad Bloch, Feodor Lynen,
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sg_vii - Massachusetts Institute of Technology 5.13:...

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