4_27_05 - Angew Chem Int Ed 1998 37 1987 Figure removed due...

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Massachusetts Institute of Technology Organic Chemistry 5.512 April 27, 2005 Prof. Rick L. Danheiser Unit 7 Stereocontrolled Reduction of Ketones Substrate Control: 1,2-Asymmetric Induction Substrate Control: 1,3-Asymmetric Induction Reagent Control Strategies Retrosynthetic Analysis: Chiral Secondary Alcohols General Review "Enantioselective Reduction of Ketones" Itsuno, S. Organic Reactions 1998 , 52 , 395 Reagent Control Strategies (1) Itsuno-Corey Reduction ("CBS Reduction") Review: "Reduction of Carbonyl Compounds with Chiral Oxazaborolidine Catalysts: A New Paradigm for Enantioselective Catalysis and a Powerful Synthetic Method" Corey, E. J.; Helal, C. J.
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Unformatted text preview: Angew. Chem. Int. Ed. 1998 , 37 , 1987 Figure removed due to copyright reasons. Photograph removed due to copyright reasons. E. J. Corey See Organic Syntheses Coll. Vol. 9 676 (2) Noyori Asymmetric Hydrogenation R Z: OH R OH Z: R O Z: R OH Z: R Z: O R Z: OH H 2 ( R )-BINAP-Ru H 2 ( S )-BINAP-Ru H 2 ( )-BINAP-Ru H 2 ( )-BINAP-Ru Photograph removed due to copyright reasons. R. Noyori et al. J. Am. Chem. Soc. 1988, 110 , 629 Also see R. Noyori et al. Organic Syntheses Coll. Vol. 9 589 Table removed due to copyright reasons....
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This note was uploaded on 11/27/2011 for the course CHEM 5.43 taught by Professor Timothyf.jamison during the Spring '07 term at MIT.

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4_27_05 - Angew Chem Int Ed 1998 37 1987 Figure removed due...

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