12_shikimate

12_shikimate - 5.451 F2005 Saccharide Biosynthesis Deoxy...

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5.451 F2005 Saccharide Biosynthesis Deoxy sugar biosynthesis review Amination requires the presence of a keto group; otherwise timing not specified Me O PMP Me O H 2 N 4,6 dideoxy± HO HO O ONDP ONDP Me tautomerization Me O PMP Me O O O HO HO Desosimine --> erythromycin H 2 N HO O ONDP ONDP ONDP
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5.451 F2005 Shikimate Pathway Normally usd in synthesis of aromatic amino acid Branch points from a primary metabolic pathway to make a variety of natural products 1. phenyl-glycine amino acids --> vancomycin --> comparison (incorporated peptide products) PKS 2. amino shikimate --> rifamycin --> PK product 3. cyclohexyl CoA --> avermectins --> incorporated into a PK product 4. coumaryl CoA derivatives for flavonoid biosynthesis starting materials
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J 5.451 F2005 Shikimate Pathway transfer plant genes to e. coli + express S.A. in e.coli another technique 28g/L culture presence of a solid ion exchange resin 14% yield based glucose starting material Figure removed due to copyright reasons. Please see Scheme 1a in
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12_shikimate - 5.451 F2005 Saccharide Biosynthesis Deoxy...

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