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ps1 - 5.451 F2005 Problem Set 1 1(25 pts Shown below is the...

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5.451 F2005 Problem Set 1. 1. (25 pts) Shown below is the structure of the cyclic peptide cystothiazole, a potent antibiotic, produced by the bacteria Cystobacter fuscus . Draw a reasonable biosynthetic pathway that includes chemical structures of intermediates and the names or abbreviation of the types of enzymes involved. N S S N 3 H 3 3 O OCH CO OCH cystothiazole Professor Sarah O'Connor Massachusetts Institute of Technology
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5.451 F2005 Problem Set 1. 2. (25 pts) Predict the structure of the polyketide that is encoded by the following set of enzymes. KS-Q AT-mm ACP KS AT-mm KR ACP KS AT-m DH KR ACP KS AT-mm ACP KS AT-mm DH ER KR ACP KS AT-mm KR ACP KS AT-mm ACP TE enzyme 1 enzyme 2 enzyme 3 Professor Sarah O'Connor Massachusetts Institute of Technology
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5.451 F2005 Problem Set 1. 3. (20 pts) Labeling studies have shown that the following molecule from Streptomyces coelicolor is made up of one unit of proline, one unit of serine, one unit of glycine and multiple units of acetate (i.e. malonyl CoA). The biosynthetic pathway is convergent,
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