ps2 - 5.451 F2005 Problem Set 2. 1. (30 pts) Draw a...

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5.451 F2005 Problem Set 2. 1. (30 pts) Draw a plausible biosynthetic pathway of the following sugars starting from glucose. Specific enzyme names and detailed mechanisms are not required, but iindicate the general type of enzyme along with any cofactor that is used. A OH B HO O O HO HO MeHN ONDP ONDP Professor Sarah O'Connor Massachusetts Institute of Technology
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5.451 F2005 Problem Set 2. 2. (30 pts) A. In a recent study, the “Des V” gene of the desosamine biosynthetic pathway was knocked ou of a desosamine producing organism (see page 15 of the sugar handout, 9/22). Draw the structure of the saccharide that would be expected to be formed from this knockout strain. B. A non-specific reductase is present in the producing organism,; draw the structure of the saccharide that would be expected to be formed under these conditions. C. The “Des I” gene was knocked out of the producing organism (containing the nonspecific reductase) and replaced with StrM from the streptosamine pathway
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This note was uploaded on 11/27/2011 for the course CHEM 5.43 taught by Professor Timothyf.jamison during the Spring '07 term at MIT.

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ps2 - 5.451 F2005 Problem Set 2. 1. (30 pts) Draw a...

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