ps3 - intermediates and utilize arrows to indicate the flow...

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5.451 F2005 Problem Set 3. 1. (25 pts) Using your knowledge of the 20 proteogenic amino acids, propose the starting material as well as a mechanism of biosynthesis for the following alkaloid. General acid bases catalysis and an oxygenase reaction is utilized. H N N H 2 O H H NH HN OH OH Professor Sarah O'Connor Massachusetts Institute of Technology
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5.451 F2005 Problem Set 3. 2. (25 pts) Propose 3 naturally occuring starting materials and a mechanism (using general acid/base catalysis) for assembling them to yield the following alkaloid. N H O O H HN NH Professor Sarah O'Connor Massachusetts Institute of Technology
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5.451 F2005 Problem Set 3. 3. (25 pts) A-E. Monoterpene biosynthesis. Draw the mechanism of biosynthesis for each of the following monoterpenes starting from geranyl diphosphate. Include all
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Unformatted text preview: intermediates and utilize arrows to indicate the flow of electrons. These reactions are enzymatically catalyzed by a terpene cyclase, so utilize general acid/base catalysis. A B C D E OH Professor Sarah O'Connor Massachusetts Institute of Technology 5.451 F2005 Problem Set 3. 4. (25 pts) Sesquiterpene biosynthesis. Propose a detailed mechanism of biosynthesis from farnesyl diphosphate for the following unusual sesquiterpene. (The last step that converts the intermediate to the final product is not typically observed in terpene biosynthesis.) terpene farnesyl cyclase [intermediate] diphosphate Professor Sarah O'Connor Massachusetts Institute of Technology...
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This note was uploaded on 11/27/2011 for the course CHEM 5.43 taught by Professor Timothyf.jamison during the Spring '07 term at MIT.

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ps3 - intermediates and utilize arrows to indicate the flow...

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