Lecture14 part 2

Lecture14 part 2 - Lecture 18 Hormones Endocrine System...

Info iconThis preview shows pages 1–11. Sign up to view the full content.

View Full Document Right Arrow Icon
Lecture 18: Chapter 45
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
hormone - in multicellular organisms, one of many types of circulating chemical signals that are formed in specialized cells, travel in body fluids, and act on specific target cells to change their functioning endocrine system - the internal system of chemical communication involving hormones, the ductless glands that secrete hormones, and the molecular receptors on or in target cells that respond to hormones; functions in concert with the nervous system to effect internal regulation and homeostasis
Background image of page 2
Cartoon of hormonal signaling
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Stages in conversion of hormonal signal to cellular response reception = binding of hormone by target cell receptor transduction = conversion of hormone signal to signal that will actually elicit cellular response response = transduced signal triggers cellular response (e.g., transcription of genes, enzymatic activity, or change in cytoskeleton)
Background image of page 4
different receptors are specific for different hormones - lock and key recognition necessary for cellular response to hormone signal - distinguish target cell from non-target cell receptor can reside on cell surface or inside the cell e.g., testosterone binds cytoplasmic receptor and induces change in receptor - leads to altered gene transcription
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Steroid hormones, such as testosterone, are able to freely cross the plasma membrane and enter the cell; thus receptors for steroid hormones are typical inside the cell Steroid hormones will enter all cells in the body, but a response will only be elicited in cells with the receptor
Background image of page 6
Membrane receptor for hormone Example: hormone > GPC- receptor > G-protein > enzyme > > > > cellular response
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Recap: water-soluble vs. lipid soluble hormones, and their receptors
Background image of page 8
A single hormone may elicit different cellular responses in different cells due to different receptors or different intracellular proteins
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Paracrine signalling = local regulators conveying signals to neighboring cells (non-hormonal) cytokines produced by helper T cell to locally activate B cells and cytotoxic T cells
Background image of page 10
Image of page 11
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

Page1 / 28

Lecture14 part 2 - Lecture 18 Hormones Endocrine System...

This preview shows document pages 1 - 11. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online