Carbohydrate Metabolism III

Carbohydrate Metabolism III - Carbohydrate Metabolism 3...

Info iconThis preview shows pages 1–10. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Carbohydrate Metabolism 3 Reading: Gropper 4 th ed, Ch 1, pp. 6–7; Ch 3, pp. 62–69; Ch 4, pp. 93–99 Gropper 5 th ed, Ch 1, pp. 6–8; Ch 3, pp. 88–100 2 Objectives for today: • Review the electron transport chain and oxidative phosphorylation • Overview of the “shuttle systems” – Malate-aspartate shuttle – Glycerol-3-P shuttle • Hexosemonophosphate shunt – (HMP shunt, pentose phosphate pathway, phosphogluconate pathway) • Gluconeogenesis 3 4 Endoplasmic reticulum Ribosome Plasma membrane Mitochondrion Polysome Stress fibers Microtrabecular strand Microtubule Fig. 1-8, p. 6 5 Ribosome Cristae DNA Outer membrane Inner membrane Matrix space Respiratory stalks Fig. 1-9, p. 6 6 Fatty acids Outer membrane Inner membrane CO 2 Pyruvate Fatty acids Acetyl CoA Krebs cycle NADH ADP + P ATP ATP P e H + H 2 O O 2 Fig. 1-10, p. 7 O 2 CO 2 H + H + Pyruvate ADP + Glycolysis 7 Fig. 4-14, p. 88 Glycolysis 8 NADH: The Shuttle Systems • NADH produced in the cytosol in glycolysis cannot enter mitochondria directly – NADH donates reducing equivalents (H + ) to a carrier (malate or glycerol-3-P) – The carrier enters the mitochondrial matrix and is used to reduce NAD + to NADH – The NADH produces 3 ATP by electron transport • Two predominate shuttle systems are: – Malate-Aspartate Shuttle – Glycerol 3-Phosphate Shuttle 9 Malate-Aspartate Shuttle • Functions in liver, kidney, and heart • In cytosol, NADH is used to convert oxaloacetate to malate • Malate is freely permeable to inner mitochondrial membrane • Malate is oxidized to oxaloacetate, generates NADH, H+...
View Full Document

This note was uploaded on 11/25/2011 for the course NTR 342 taught by Professor Tillman during the Spring '09 term at University of Texas.

Page1 / 33

Carbohydrate Metabolism III - Carbohydrate Metabolism 3...

This preview shows document pages 1 - 10. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online