10:06:2011- - Vitamin D Discovery Rickets • Documentation of rickets as early as 1650 by physicians in England • Disease was associated with

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Unformatted text preview: Vitamin D Discovery- Rickets • Documentation of rickets as early as 1650 by physicians in England. • Disease was associated with children in cities found in northern latitudes, children were described as having “soft bones.” • Blamed on array of causes: poor sanitation, lack of exercise, dirty clothes and syphyllis • In the 1800’s a French physician, Armand Trousseau, was able to connect rickets in children with osteomalacia in adults. Also identified cold and sunless climates and poor diet as causes. Used cod-liver oil, prolonged breast feeding if mother’s milk as good and sun exposure for treatment. Eighteenth century – industrial revolution led to ↑ in rickets. 1) burning coal – smog 2) ↑factory work 3) ↑child labor Discovery continued • Initial studies were with lion cubs in the London Zoo and puppies. lions recovered when fed bones, milk and cod-liver oil, puppies recovered when fed butterfat and cod-liver oil and exercise outside. Initially missed on the puppies – thought vitamin A in the diet and actual exercise were the cure. • Orphanages in post WWI in Berlin offered opportunities to work with rickets. • Huldschinsky used a sun lamp (provided UV rays) to cure rickets in babies. • Harriette Chick used controlled diet studies of orphans and found: 1) Toddlers were prone to development. 2) Sunshine and cod-liver oil prevented and cured. 3) Huldschinsky’s mercury vapor lamp cured rickets. 4) Rickets was worse in the winter. 5) Fresh air and exercise did not prevent or treat rickets. Discovery continued 1917 – McCollum and Howland (pediatrician at Johns Hopkins) produced rickets in rats – x-rayed the boned to demonstrate the relationship to...
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This note was uploaded on 11/25/2011 for the course NTR 365 taught by Professor Sweltzer during the Fall '11 term at University of Texas at Austin.

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10:06:2011- - Vitamin D Discovery Rickets • Documentation of rickets as early as 1650 by physicians in England • Disease was associated with

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