Vitamin K 2011 - Vitamin K 1929 Danish scientist Henrik Dam...

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Vitamin K 1929 Danish scientist Henrik Dam investigated role of cholesterol by feeding chickens a cholesterol deficient diet. chickens developed hemorrhages and started bleeding. Adding cholesterol back to the diet did not correct it . A second compound was missing – called it the coagulation vitamin. Edward Adelbert Doisy of Saint Louis University determined structure. Dam and Doisy received the Nobel Prize for their work in 1943.
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For several years the vitamin K-deficient chick model was the only method of quantifying Vitamin K in various foods: measured restoration of blood coagulation. The first published report of successful treatment with vitamin K of life- threatening hemorrhage in a jaundiced patient with prothrombin deficiency was made in 1938 .
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Structure Vitamin K is: a group of vitamins needed for the posttranslational modification of certain proteins, mostly required for blood coagulation. All structures of vitamin K contain a 2-methyl 1,4 naphthoquinone ring Synthetic forms: K 3 (menadione), K 4 , K 5 Natural forms : K 1 – phylloquinone K 2 – menaquinone – in the body listed as MK-n (n is the number of repeating 5- carbon units)
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Vitamin K 2011 - Vitamin K 1929 Danish scientist Henrik Dam...

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