12_HIV_NiedFall2011 - HIV http://youtu.be/axwNyWNbFb4 full...

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Unformatted text preview: HIV http://youtu.be/axwNyWNbFb4 full science of HIV http://uctv.canterbury.ac.nz/modules/ journal/entry.php? space_key=4&module_key=137&post _key=1116&journal_user_key=0 History of HIV patient 0 DR. S.K CHATURVEDI Lesson objectives Understand the global and local impact of the epidemic Know about HIV/AIDS in adults, children, and families Understand the natural history of HIV infection Understand the modes of HIV transmission Scope of the HIV/AIDS Pandemic Natural History and Transmission of HIV HIV H uman I mmunodeficiency V irus H = Infects only H uman beings I = I mmunodeficiency virus weakens the immune system and increases the risk of infection V = V irus that attacks the body AIDS A cquired I mmune D eficiency S yndrome A = A cquired, not inherited I = Weakens the I mmune system D = Creates a D eficiency of CD4+ cells in the immune system S = S yndrome, or a group of illnesses taking place at the same time DR. S.K CHATURVEDI HIV and AIDS When the immune system becomes weakened by HIV, the illness progresses to AIDS Some blood tests, symptoms or certain infections indicate progression of HIV to AIDS HIV a Virus Glycoprotein that attaches with gp 120 to CD4 receptor Inside cell RNA transcribed to DNA by RT DNA incorporated into cell genome DNA is copied and translated to viral enzymes, proteases New infectious virus buds from host cell to repeat process AIDS is now second only to the Bl ack Death as the largest epidemic in history. UNAI DS estimate 25 million peo ple have been killed by it since its reco gnition in 1981 AIDS kills over 2 million people a year, or about one person every 15 seconds. This death toll surprisingly includes a lot of children, who are often infected wi th the HI V virus during pregnancy or through breast-feeding. Joint United Nations Program on HIV/AIDS (UNAIDS), World Health Organization (WHO) AI DS as a mode rn pl ag ue AI DS as a mode rn pl ag ue Slightly over 0.6% of the wo rld is infected The toll is worst in Af rica, wh ere millions of parents have died, leav ing chi ldren as orphans. Of ten teac hers have died as we ll, leav ing schools empty. Doctors and nurses hav e died, leav ing hospitals and medical clinics wi th nothing. Farmers have died, leav ing crops in the fields. En tire villages have been devastated. Joint United Nations Program on HIV/AIDS (UNAIDS), World Health Organization (WHO) HI V in hu mans HIV- 1 was the original HI V discovered, and is global and more transmissible than HI V- 2, which is supposed to be restricted to We st Af rica HIV- 2 transmits from mother to child at a lower rate than HI V- 1 Rec ent research suggests that circumcision of males may reduce transmissibility of HIV First study in 1995 on truckers in Ke nya Nex t study more comp rehensive, involved WH O data Williams BG, Lloyd-Smith JO, Gouws E, Hankins C, Getz WM, et al (2006) The potential impact of male circumcision on HIV in sub-Saharan Africa. PLoS Med 3: e262. DR. S.K CHATURVEDIDR....
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This note was uploaded on 11/25/2011 for the course NTR 321 taught by Professor Niederreither during the Spring '11 term at University of Texas at Austin.

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12_HIV_NiedFall2011 - HIV http://youtu.be/axwNyWNbFb4 full...

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