Ch_24_Cancer_Cells

Ch_24_Cancer_Cells - Cancer Cells Biol-003 A. Cancer...

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Cancer Cells Biol-003 Spring 2010 A. Cancer Defined 1. Cancer (L crab )—diseases in which tissues grow and spread throughout body a. Carcinomas b. Sarcomas c. Lymphomas and leukemias 2. Properties that define cancer a. Uncontrolled proliferation (cell division) b. Ability to spread (metastasize) 3. Cancer cells have accumulated genetic defects a. Tumor suppressor functions lost b. Ability to trigger cell death (apoptosis) lost c. Regulation of cell division (mitosis) lost d. Proto-oncogenes converted into oncogenes B. Cell Cycle and Cancer 1. Stages/phases of cell cycle a. Interphase b. Mitosis c. Cytokinesis 2. Transition from one phase to another depends on chemical signaling (internal and external) a. Proteins called cyclins b. Enzymes called kinases c. Products of oncogenes → changes in cell growth and metabolism that contribute to cancer C. Hallmarks of Cancer Cells 1. Self-sufficiency in growth signals or response a. Oncogenes produce excess growth factors b. Oncogenes produce mutant versions of proteins in growth-stimulating pathway
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This note was uploaded on 11/25/2011 for the course BIO 3 taught by Professor Dylan during the Spring '11 term at Evergreen Valley.

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Ch_24_Cancer_Cells - Cancer Cells Biol-003 A. Cancer...

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