DNA_Chips_to_Lab_on_a_Chip

DNA_Chips_to_Lab_on_a_Chip - Lab-on-a-chip glass device DNA...

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DNA Chips to Lab-on-a-Chip Janice Toyoshima Evergreen Valley College Janice.toyoshima@evc.edu IISME Summer Fellow 2009 Lab-on-a-chip glass device
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Outline Historical perspective technology timeline Design concerns and fabrication Fabrication Applications Diagnostic tests medical, food safety Defense and security Environmental monitoring Research
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Timeline of Biosensor Development 1950s 1954—Microtechnology invented 1956—Oxygen electrode invented 1960s 1962—Glucose enzyme electrode Pressure sensor Airbag sensor Fluid handling devices 1969—Potentiometric enzyme electrode for urea 1970s A lot of research went on in the late 1950s and1960s as part of the ―space race‖ with the former Soviet Union
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1970s Timeline of Biosensor Development 1974—Thermal enzyme probes/enzyme thermistors developed 1980s 1976—LaRoche introduces lactate analyzer enzyme electrode 1976—Electrochemical glucose sensor (commercial product) 1975—Fiber optic sensor with immobilized indicator for O 2 or CO 2 1975—Amperometric glucose analyzer (Yellow Spring Instrument Co., Ohio) 1975—microbioal electrode for alcohol measurements 1975—First lab-on-a-chip (LOC) analysis system for gas chromatography Continuation of research from the 1960s but also start to see commercialization of inventions
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Timeline of Biosensor Development 1990s 1980s Micropumps 1987—DNA collections arranged in arrays to detect active gene 1988—Biosite introduces Triage System for measuring blood proteins Integrated fluid treatments (pre- treatment, separation, detection) Flow sensors 1982—In vivo enzyme electrode glucose sensor 1983—SPR to monitor immuno- affinity reactions in real time 1984—Immobilized ferrocene mediators for oxidoreductase enzyme electrodes 1987—MediSense launches pen- sized glucose monitors with screen- printed enzyme electrodes Research continues; rise of biotechnology; more inventions enter the market
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Timeline of Biosensor Development 1994—Affymetrix introduces GeneChip (miniaturized DNA microarray for gene expression analysis) 1995—CombiMatrix introduces CustomArray (integrated circuit with microarrays of electrodes to assemble biopolymers) 1998—Nanogen introduces NanoChip (integrated circuit places DNA in specific location on chip 1999—Agilent introduces LabChip (DNA printed on chip using inkjet technology 1997—complete geneome of Sacchromyces cerevisiae on microarray 1990s 21 st century 1990—Biacore uses SPR as base technology for its biosensing products (lab-on-a-chip technology) 1992—i-STAT launches hand-held blood analyzer with lab-on-a- chip test strips More inventions from the previous decade(s) hit the market place
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Timeline of Biosensor Development 2005—STMicroelectronics introduces In-Check microarray to detect specific bacterial strains Ongoing—research and development of nanobiosensors
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This note was uploaded on 11/25/2011 for the course BIO 3 taught by Professor Dylan during the Spring '11 term at Evergreen Valley.

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DNA_Chips_to_Lab_on_a_Chip - Lab-on-a-chip glass device DNA...

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